I am sorry but i donât understand your abbreviations. Cefepime should be considered only in non-severe infections (eg, uncomplicated urinary tract infection) when the minimum inhibitory concentration (MIC) is 2 mg/L or less (1). Introduction. When geriatric patients received the usual recommended adult dose, clinical efficacy and safety were comparable to clinical efficacy and safety in non-geriatric adult patients. Hope your query is answered. 1 doctor agrees. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. To learn more, please visit our. Constitute cefepime for injection vials 1 gram and 2 grams with one of the following diluents: Sterile Water for Injection, 0.9% Sodium Chloride, 5% Dextrose Injection, 0.5% or 1% Lidocaine Hydrochloride, or Sterile Bacteriostatic Water for Injection with Parabens or Benzyl Alcohol. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. Anaphylaxis including anaphylactic shock, transient leukopenia, neutropenia, agranulocytosis and thrombocytopenia, have been reported. eHealthMe makes it possible for everyone to run personal clinical trial. Pregnancy Category B The generic name of Cefepime is cefepime. Cefepime for injection should be administered at the same time each day and following the completion of hemodialysis on hemodialysis days (see Table 2). Limit to 1 drink or 1 glass of wine. In patients whose fever resolves but who remain neutropenic for more than 7 days, the need for continued antimicrobial therapy should be re-evaluated frequently. MAXIPIME (cefepime hydrochloride) Injection. The absolute bioavailability of Cefepime after an intramuscular dose of 50 mg per kg was 82.3 (±15)% in eight patients. Cefepime is metabolized to N-methylpyrrolidine (NMP) which is rapidly converted to the N-oxide (NMP-N-oxide). Table 13: Pooled Response Rates for Empiric Therapy of Febrile Neutropenic Patients, Primary episode resolved with no treatment modification, no new febrile episodes or infection, and oral antibiotics allowed for completion of treatment, Primary episode resolved with no treatment modification, no new febrile episodes or infection and no post-treatment oral antibiotics, Survival, any treatment modification allowed, Primary episode resolved with no treatment modification and oral antibiotics allowed for completion of treatment, Primary episode resolved with no treatment modification and no post-treatment oral antibiotics. No animal carcinogenicity studies have been conducted with Cefepime. The chemical name is 1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)-glyoxylamido]-2-carboxy-8oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl]methyl]-1-methylpyrrolidinium chloride,7 2-(Z)-(Omethyloxime), … There were no deaths or permanent disabilities thought related to drug toxicity. Table 12: Demographics of Evaluable Patients (First Episodes Only), ANC = absolute neutrophil count; SBP = systolic blood pressure. The pharmacokinetics of Cefepime were unaltered in patients with hepatic impairment who received a single 1 g dose (n=11). CEFEPIME (SEF e pim) is a cephalosporin antibiotic. However, the pharmacokinetic/pharmacodynamics relationship for Cefepime has not been evaluated in patients. Repeated evaluation of the patient’s condition is essential. It works by fighting bacteria in your body. It does not interfere with the effectiveness of the medication. Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Cefepime for injection, and may range in severity from mild diarrhea to fatal colitis. Limit to 1 drink or 1 glass of wine. Everything you need to know about taking this antibiotic to treat bacterial infections, including single dose cefixime 400 mg with azithromycin for gonorrhoea and possible side effects Encephalopathy (disturbance of consciousness including confusion, hallucinations, stupor, and coma), aphasia, myoclonus, seizures, and nonconvulsive status epilepticus have been reported. Cefepime for Injection Admixture Incompatibility. Similar to other beta-lactam antimicrobial agents, the time that the unbound plasma concentration of Cefepime exceeds the MIC of the infecting organism has been shown to best correlate with efficacy in animal models of infection. Monitor renal function if aminoglycosides are to be administered with Cefepime for injection because of the increased potential of nephrotoxicity and ototoxicity of aminoglycoside antibacterial drugs. The overall clinical cure rate among the primary analysis patients was 81% (51 cured/63 evaluable patients) in the Cefepime plus metronidazole group and 66% (62/94) in the imipenem/cilastatin group. Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy. Cefepime for injection vials are compatible at concentrations between 1 mg per mL and 40 mg per mL with the following intravenous infusion fluids: 0.9% Sodium Chloride Injection, 5% and 10% Dextrose Injection, M/6 Sodium Lactate Injection, 5% Dextrose and 0.9% Sodium Chloride Injection, Lactated Ringers and 5% Dextrose Injection, Normosol™-R, and Normosol™-M in 5% Dextrose Injection. The following adverse reactions are discussed in the Warnings and Precautions section and below: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Monitor renal function when Cefepime is concomitantly administered with potent diuretics. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. A similar safety profile was seen in clinical trials of pediatric patients. amoxicillin, doxycycline, metronidazole, azithromycin, cephalexin, ciprofloxacin, Keflex, clindamycin, Augmentin, levofloxacin. It is highly soluble in water. Drinking alcohol while taking Flagyl can cause serious side effects. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Labeler Name: Wg Critical Care, Llc Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Hypertoxin-producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. lwoffii. Protect from light. Cefepime is widely used in the hospital setting, and only a few studies have reported neurotoxicity and nephrotoxicity as side effects of this drug. By using our website, you consent to our use of cookies. There is no drug interaction reported. Select one or more newsletters to continue. Table 12 describes the characteristics of the evaluable patient population. It is used to treat many kinds of infect ... is there any interaction between cefixime and alcohol? To date, clinical studies comparing cefepime vs carbapenem have been small and/or retrospective, often with conflicting results (1). Cefixime is an antibiotic in the cephalosporin class. Freshly constituted solutions of Cefepime for Injection, USP will range in color from pale yellow to amber. For non-prescription products, read the label or package ingredients carefully. Use of Cefepime for injection in these age groups is supported by evidence from adequate and well-controlled studies of Cefepime in adults with additional pharmacokinetic and safety data from pediatric trials [see Clinical Pharmacology (12.3)]. The pharmacokinetics of Cefepime are linear over the range of 500 mg to 2 g intramuscularly and do not vary with respect to treatment duration. Cefepime pharmacokinetics have been evaluated in pediatric patients from 2 months to 11 years of age following single and multiple doses on every 8 hours (n=29) and every 12 hours (n=13) schedules. There are no adequate and well-controlled studies of Cefepime use in pregnant women. Of the more than 6,400 adults treated with Cefepime for injection in clinical studies, 35% were 65 years or older while 16% were 75 years or older. Call your doctor immediately if diarrhea doesn’t stop, and you notice blood in your stools. RT/L = Ambient room temperature and light. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. in combination with metronidazole). No data are available in patients with septic shock. Cefepime for injection is indicated in the treatment of uncomplicated skin and skin structure infections caused by Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes. 50 mg/kg/dose IV every 8 to 12 hours (Max: 2 g/dose). Do not consume. Caution should be exercised when Cefepime is administered to a nursing woman [see Clinical Pharmacology (12.3)]. Although doctors do not advise mixing medicines with alcohol, only a few are actually affected by the combination with alcohol. Guidelines recommend cefepime plus vancomycin, gentamicin, and rifampin (if prosthetic material is present) for culture-negative nosocomial endocarditis associated with vascular cannulae or early (less than 1 year after surgery) prosthetic valve endocarditis; treat for 4 to 6 weeks, with a longer course for PVE. Cefepime belongs to a group of drugs called cephalosporin antibiotics, which work to stop the growth of bacteria in the body. 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