Hans Clevers (Hubrecht Institute): "These organoids contain the cells of the human intestinal lining, making them a compelling model to investigate infection by SARS-CoV-2." 9 Oncode Institute, Utrecht, the Netherlands. Researchers from the group of Hans Clevers at the Hubrecht Institute (KNAW), in an international collaboration, have developed a method to grow snake venom gland cells as organoids. During his life Hubrecht assembled a vast amount of embryonic material from a number of species, particularly from the former Dutch colonies of the East Indies. Developmental Biology and Stem Cell Research 2017 – present  Shaw Prize, Hong Kong 10 The Princess Maxima Center for Pediatric Oncology, Utrecht, … At the start of their PhD, the PhD students draft a Training & Supervision Agreement (TSA) and during their PhD they have yearly meetings with their supervisory committee, which includes 2-3 independent researchers. Life Sciences and Health is one of the main themes of research and education. Hans Clevers ‡ Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen, and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands. Utrecht Science Park is only 15 minutes away from downtown Utrecht: a lively, charming university town. 2017    Princess Takamatsu Award of Merit, Tokyo Cell 176:1158-1173 (2019), 57)          Schutgens F., Rookmaaker, M.B., Margaritis, T., Rios, A., Ammerlaan, C., Jansen, J., Gijzen, L., Vormann, M., Vonk, A., Viveen, M., Yousef Yengej, F., de Winter – de Groot, K.M., Artegiani, B., van Boxtel, R., Cuppen, R., Hendrickx, A.P.A., van den Heuvel – Eibrink, M.M., Heitzer, E., Lanz, H., Beekman, J., Murk, J., Masereeuw, R., Holstege, F., Drost, J., Verhaar, M.C., Clevers, H. Human Adult Kidney-derived Tubuloids as Personalized Disease Models in a Dish and on a Chip h.clevers@hubrecht.eu. In the UMC Utrecht, research is concentrated in six programs with each a limited number of disease targets. This was echoed by an independent scientific evaluation: “In the opinion of the committee, the quality of science done at the Hubrecht Institute is equal to that of the best research institutions in the world”. h.clevers@hubrecht.eu. Alexander van Oudenaarden, Hans Clevers. And Clevers, H. Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H . ↵ † Present address: … Hans Clevers is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. All of these PhD students are affiliated with the Cancer, Stem Cells and Developmental Biology (CS&D) program of the Graduate School of Life Sciences (GSLS). This technology is based on the discovery of the LGR5 positive adult epithelial stem cell, first identified in the intestine by the group headed by Prof. Hans Clevers. Research groups. In this video, Hans Clevers summarizes the use of organdies in cancer research. Science  358: 234-238 (2017). Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or … Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. Gijs van den Brink. Cell 136: 903-912 (2009), 27)           Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., and Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. ‪Hubrecht Institute - Utrecht‬ - ‪Cited by 173,529‬ - ‪Wnt‬ - ‪Intestine‬ - ‪Organoid‬ - ‪Adult stem cell‬ Since 2008, the Hubrecht is affiliated with the UMC Utrecht. 17 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands. Culturing heart tissue. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. 2000               Member of the Royal Netherlands Academy of Sciences (KNAW) 19. Prof. Dr. James Sharpe, EMBL, Barcelona Nature 476: 293-297 (2011), 34)           Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers H. Wnt signaling inhibits proteasomal β-catenin degradation within a compositionally intact Axin1 complex. and Clevers, H. van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., ... Garnett, M.J., Clevers, H. Boj, S.F., Hwang, C.I., Baker, L.A., Chio, I.I., Engle, D.D., ..., Clevers, H, Tuveson, D.A. 2005    The Science and Society Prize, Amsterdam 2017                     Kovalenko Medal, National Academy of Sciences Washington, 2002 – present  Central South University, Chang Sha, China 2005    The French honor of “Chevalier de la Legion d’Honneur” 1991 – 2002      Professor and Chairman, Dept. Nature 556, 437-462 (2018). 11 Oncode Institute, Hubrecht Institute-KNAW and UMC Utrecht, Utrecht, The Netherlands h.clevers@hubrecht.eu. 53)           Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. 2020 – present  Member of the Scientific Advisory Board of Volestra Therapeutic Inc., New York The tumor suppressor protein APC forms the core of a cytoplasmic complex which binds ß-catenin and targets it for degradation in the proteasome. Nature  406: 527-532 (2000), 12)           Bienz, M., and Clevers, H. Linking colorectal cancer to Wnt signaling. Maurice, M.M. 2017 – present  Oncode Investigator Year; Wnt/β-catenin signaling in development and disease. Science 340: 1190-1194 (2013), 41)           Clevers, H. The intestinal crypt, a prototype stem cell compartment. Organoid models of human and mouse ductal pancreatic cancer. Review. Cell 111: 251-263 (2002), 15)           Hurlstone, A.F., Haramis, A.P., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H., Clevers, H. The Wnt/beta-catenin pathway regulates cardiac valve formation. The cornerstones of Oncode are excellent research, intensive cooperation and bringing new treatments faster to the clinic. In 2007 the name was changed from Hubrecht Laboratory to Hubrecht Institute. The Hubrecht is a highly dynamic, diverse and young institute where the average age of the researchers is around 30 and more than 30 different nationalities are represented. Nature 469: 415-418 (2011). Human organoids are readily amenable to CRISP-mediated genome modification to model for instance malignant transformation (48) and mutagenesis upon faulty DNA repair (52). Nature 521: 43-47 (2015), 50)           Farin, H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K., Angers, S., Peters, P.J. More than 10 years after the cultivation of the first organoid – at the Hubrecht Institute by Toshiro Sato in the group headed by Hans Clevers – the path to commercial applications is open. Review. 2019 – present  Foreign Advisory Board Member of Consortium for Neogenetic Medicine, Tokyo, 1999               Member European Molecular Biology Organisation (EMBO) Hubrecht Organoid Technology or HUB was founded around Organoid Technology. The Princess Máxima Center has open her own new hospital and research building at the Utrecht Science Park in May 2018. 2016 – present  Member of the Scientific Advisory Board of Surrozen, San Francisco It promotes quality in science and scholarship and strives to ensure that Dutch scholars and scientists contribute to cultural, social and economic progress. And Clevers, H. Xtcf-3 Transcription factor mediates beta-catenin-induced axis formation in xenopus embryos. 3 Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M.A., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, S., van de Wetering, M., Sasaki, N., Boers, S.J., Kemperman, H., de Jonge, J., Ijzermans, J.N.M., Niewenhuis, E.E.S., Hoekstra, R., Strom, S., Vries, R.G.J., van der Laan, L.J.W., Cuppen, E., Clevers, H. Karthaus, W.R., Iaquinta, P.J., Drost, J., Gracanin, A.., van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H. Ritsma, L., Ellenbroek, S.I., Zomer, A., Snippert, H.J., de Sauvage, F.J., Simons, B.D., Clevers, H., van Rheenen, J. Schwank, G., Koo, B.K., Sasselli, V., Dekkers, J.F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C.K., Nieuwenhuis, E.E., Beekman, J.M. 220 were here. 4 Allen Institute for Brain Science, Seattle, WA, USA. Science 364:952-955 Review (2019), Lamers MM, Beumer J, van der Vaart J [...] Haagmans, BL, Clevers H, Post Y, Puschhof J, Beumer B [...] Casewell NR, Clevers H, Pleguezuelos-Manzano C, Puschhof J, Rosendahl A [...] van Boxtel R, Clevers H, Kopper O, de Witte, CJ [...] Kloosterman WP, Clevers H, Schutgens F, Rookmaaker MB [...] Verhaar MC, Clevers H, Gehart H, van Es J, [...] Rios A, and Clevers H, Hu H, Gehart H [...] de Jong YP, Clevers H, Roerink SF, Sasaki N [...] Stratton MR, Clevers H, Sachs N, de Ligt J [...] Cuppen E, Clevers H, Drost J, van Boxtel R [...] Cuppen E, Clevers H. Drost, J, van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Farin, H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K., Angers, S., Peters, P.J. The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues and organisms. Hubrecht Organoid Technology or HUB was founded around Organoid Technology. 9 Hubrecht Organoid Technology, Utrecht, The Netherlands. In mammals, physiological Wnt signaling is intimately involved with the biology of adult stem cells and self-renewing tissues (18,19). Researchers from the group of Hans Clevers at the Hubrecht Institute have modeled the development and progression of high-grade serous ovarian cancer in mini-versions of the female reproductive organs of the mouse. 2012 – 2015      President of the Royal Netherlands Academy of Sciences (KNAW), Amsterdam 2015                     Pezcoller Foundation – AACR International Award for Cancer Research, Italy Organoid models of human and mouse ductal pancreatic cancer cells ( 29 ) with Terhorst... 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